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Immobilization of Liposomes and Vesicles on Patterned Surfaces by a Peptide Coiled-Coil Binding Motif

Authors

  • Dr. Jens Voskuhl,

    1. Soft Matter Chemistry, Leiden Institute of Chemistry, P.O. Box 9502, 2300 RA Leiden (The Netherlands)
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  • Dr. Christian Wendeln,

    1. Organic Chemistry Institute and CeNTech, Westfälische Wilhelms-Universität Münster, Corrensstrasse 40, 48149 Münster (Germany)
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  • M. Sc. Frank Versluis,

    1. Soft Matter Chemistry, Leiden Institute of Chemistry, P.O. Box 9502, 2300 RA Leiden (The Netherlands)
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  • M. Sc. Eva-Corinna Fritz,

    1. Organic Chemistry Institute and CeNTech, Westfälische Wilhelms-Universität Münster, Corrensstrasse 40, 48149 Münster (Germany)
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  • M. Sc. Oliver Roling,

    1. Organic Chemistry Institute and CeNTech, Westfälische Wilhelms-Universität Münster, Corrensstrasse 40, 48149 Münster (Germany)
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  • M. Sc. Harshal Zope,

    1. Soft Matter Chemistry, Leiden Institute of Chemistry, P.O. Box 9502, 2300 RA Leiden (The Netherlands)
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  • Dr. Christian Schulz,

    1. Organic Chemistry Institute and CeNTech, Westfälische Wilhelms-Universität Münster, Corrensstrasse 40, 48149 Münster (Germany)
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  • Dipl.-Phys. Stefan Rinnen,

    1. Physikalisches Institut, Westfälische Wilhelms-Universität Münster, Wilhelm-Klemm-Strasse 10, 48149 Münster (Germany)
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  • Prof. Dr. Heinrich F. Arlinghaus,

    1. Physikalisches Institut, Westfälische Wilhelms-Universität Münster, Wilhelm-Klemm-Strasse 10, 48149 Münster (Germany)
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  • Prof. Dr. Bart Jan Ravoo,

    Corresponding author
    1. Organic Chemistry Institute and CeNTech, Westfälische Wilhelms-Universität Münster, Corrensstrasse 40, 48149 Münster (Germany)
    • Organic Chemistry Institute and CeNTech, Westfälische Wilhelms-Universität Münster, Corrensstrasse 40, 48149 Münster (Germany)
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  • Dr. Alexander Kros

    Corresponding author
    1. Soft Matter Chemistry, Leiden Institute of Chemistry, P.O. Box 9502, 2300 RA Leiden (The Netherlands)
    • Soft Matter Chemistry, Leiden Institute of Chemistry, P.O. Box 9502, 2300 RA Leiden (The Netherlands)
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  • A.K. acknowledges the support of the European Research Council by an ERC starting grant. B.J.R. acknowledges DFG for financial support (grant Ra 1732/1). Silicon wafers were kindly donated by Siltronic AG. Patrick Seelheim and Prof. Dr. H. J. Galla are acknowledged for access to and discussion of QCM-D measurements.

Abstract

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Patchy surfaces: An azide-terminated self-assembled monolayer was patterned with the peptide sequence (EIAALEK)3 by using microcontact printing. This sequence forms stable coiled-coil heterodimers with the complementary peptide (KIAALKE)3. By introducing this peptide to the surface of phospholipid liposomes and cyclodextrin vesicles, liposomes and vesicles can be immobilized at the patterned surface.

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