Enantioselective Diels–Alder Reactions with G-Quadruplex DNA-Based Catalysts


  • This work is financially supported by National Natural Science Foundation of China (grant numbers. 20773123, 20621063, 31000392). We thank Prof. Zhaochi Feng, Prof. Qihua Yang and Dr. Jun Li for helpful discussions, particular acknowledgement to Dr. Xin Zhang of the Scripps Research Institute for revising the manuscript.


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DNA in command: An enantioselective Diels–Alder reaction can be achieved using human telomeric G-quadruplex DNA-based catalysts. The absolute configuration of the product can be reversed when the conformation of G-quadruplex DNA is switched from antiparallel to parallel, and both the reaction rate and the enantioselectivity of the Diels–Alder reaction were found to be dependent on the DNA sequence.