This work is financially supported by National Natural Science Foundation of China (grant numbers. 20773123, 20621063, 31000392). We thank Prof. Zhaochi Feng, Prof. Qihua Yang and Dr. Jun Li for helpful discussions, particular acknowledgement to Dr. Xin Zhang of the Scripps Research Institute for revising the manuscript.
Enantioselective Diels–Alder Reactions with G-Quadruplex DNA-Based Catalysts†
Article first published online: 15 AUG 2012
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 51, Issue 37, pages 9352–9355, September 10, 2012
How to Cite
Wang, C., Jia, G., Zhou, J., Li, Y., Liu, Y., Lu, S. and Li, C. (2012), Enantioselective Diels–Alder Reactions with G-Quadruplex DNA-Based Catalysts . Angew. Chem. Int. Ed., 51: 9352–9355. doi: 10.1002/anie.201204850
- Issue published online: 5 SEP 2012
- Article first published online: 15 AUG 2012
- Manuscript Received: 21 JUN 2012
- National Natural Science Foundation of China. Grant Numbers: 20773123, 20621063, 31000392
- asymmetric catalysis;
- Diels–Alder reaction;
DNA in command: An enantioselective Diels–Alder reaction can be achieved using human telomeric G-quadruplex DNA-based catalysts. The absolute configuration of the product can be reversed when the conformation of G-quadruplex DNA is switched from antiparallel to parallel, and both the reaction rate and the enantioselectivity of the Diels–Alder reaction were found to be dependent on the DNA sequence.