The work was financially supported by the DFG.
Photoinduced Reductive Electron Transfer in LNA:DNA Hybrids: A Compromise between Conformation and Base Stacking†
Article first published online: 3 SEP 2012
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 51, Issue 40, pages 10026–10029, October 1, 2012
How to Cite
Wenge, U., Wengel, J. and Wagenknecht, H.-A. (2012), Photoinduced Reductive Electron Transfer in LNA:DNA Hybrids: A Compromise between Conformation and Base Stacking . Angew. Chem. Int. Ed., 51: 10026–10029. doi: 10.1002/anie.201204901
- Issue published online: 26 SEP 2012
- Article first published online: 3 SEP 2012
- Manuscript Received: 22 JUN 2012
- electron transfer;
Lock it, but not too much: LNA units (locked or bridging nucleic acids) in LNA:DNA hybrids lead to a negative effect on electron transfer (ET), but they also force the nucleic acid structure in the A-type double helix, which allows a better base stacking than the normal B-type and thus positively influences the ET. This result is significant for the design of nucleic acids of molecular electronics.