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Keywords:

  • conformation;
  • electron transfer;
  • LNA;
  • pyrene;
  • RNA
Thumbnail image of graphical abstract

Lock it, but not too much: LNA units (locked or bridging nucleic acids) in LNA:DNA hybrids lead to a negative effect on electron transfer (ET), but they also force the nucleic acid structure in the A-type double helix, which allows a better base stacking than the normal B-type and thus positively influences the ET. This result is significant for the design of nucleic acids of molecular electronics.