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Keywords:

  • cuprates;
  • density functional calculations;
  • mechanistic studies;
  • ortho metalation;
  • structure elucidation
Thumbnail image of graphical abstract

The name of the game: X-ray crystallographic analysis of Gilman- and Lipshutz-type amidocuprates indicates that the presence of LiX (X=CN, I) and THF shifts the equilibrium between the two toward the Lipshutz-type cuprate and that this is important in generating the active species for directed ortho cupration. DFT calculations show that monomeric Gilman-type cuprates have an unprecedentedly high reactivity (see scheme, DG=directing group).