Controlling Molecular Recognition with Lipid/Polymer Domains in Vesicle Membranes


  • This work was supported financially by the Deutsche Forschungsgemeinschaft (grant BI 1337/6-1 (W.H.B., M.S.) within the Forschergruppe FOR-1145; grants DFG INST 271/249-1, INST 271/247-1, INST 271/248-1 (W.H.B.)), the BMBF (ZIK HALOmem, FKZ 03Z2HN22 (K.B., S.W.)), and ERDF (grant 1241090001).


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The molecular recognition between cholera toxin B and GM1-functionalized phospholipid/block copolymer hybrid membranes can be controlled by varying the lipid/block copolymer composition. Confocal laser scanning microscopy and fluorescence correlation spectroscopy were used to study the protein–receptor interaction and dynamic processes in the membrane.