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Keywords:

  • aspartimide;
  • aspartylation;
  • glycopeptides;
  • pseudoproline dipeptide;
  • solid-phase synthesis
Thumbnail image of graphical abstract

Like a Pro: A one-flask aspartylation/deprotection method, wherein long peptide fragments, bearing proximal pseudoproline functionality, are merged with complex glycan domains has been developed. Following aspartylation, acid-mediated global deprotection reveals the elaborated glycopeptide. The temporary pseudoproline functionality serves to suppress formation of aspartimide side products during solid-phase peptide synthesis and aspartylation.