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Keywords:

  • Aspergillus fumigatus;
  • gliotoxin;
  • lyases;
  • mycotoxins;
  • organosulfur compounds
Thumbnail image of graphical abstract

Two in one go: The elucidation of a key step in the biosynthesis of gliotoxin, the infamous virulence factor of the human pathogen Aspergillus fumigatus, provides insight into the formation of an epidithiol. Isolation of a bis(cysteine) S-conjugate from a ΔgliI mutant and in vitro studies show that GliI concomitantly cleaves two C[BOND]S bonds, along with the formation of ammonia and pyruvate (see scheme).