Communication

Peptide Cross-Linking at Ambient Surfaces by Reactions of Nanosprayed Molecular Cations†

  1. Abraham K. Badu-Tawiah,
  2. Anyin Li,
  3. Fred P. M. Jjunju,
  4. Prof. R. Graham Cooks*

Article first published online: 17 AUG 2012

DOI: 10.1002/anie.201205044

Issue

Angewandte Chemie International Edition

Angewandte Chemie International Edition

Volume 51, Issue 37, pages 9417–9421, September 10, 2012

Additional Information

How to Cite

Badu-Tawiah, A. K., Li, A., Jjunju, F. P. M. and Cooks, R. G. (2012), Peptide Cross-Linking at Ambient Surfaces by Reactions of Nanosprayed Molecular Cations . Angew. Chem. Int. Ed., 51: 9417–9421. doi: 10.1002/anie.201205044

Author Information

  1. Department of Chemistry, Purdue University, West Lafayette, IN 47907 (USA)

*Department of Chemistry, Purdue University, West Lafayette, IN 47907 (USA)

  1. †

    This research was supported by the National Science Foundation CHENSF 0848650.

Publication History

  1. Issue published online: 5 SEP 2012
  2. Article first published online: 17 AUG 2012
  3. Manuscript Received: 27 JUN 2012

Funded by

  • National Science Foundation. Grant Number: CHENSF 0848650

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Keywords:

  • desorption electrospray ionization;
  • ion–surface reactions;
  • mass spectrometry;
  • peptide derivatization;
  • surface chemistry
Thumbnail image of graphical abstract

Chemical synthesis with ambient ions: Peptide cross-linking is achieved nearly instantaneously and quantitatively by delivering solvated peptide cations in microdroplets to a cross-linker present on a glass surface (see picture) or vice versa. The reaction can be carried out in an open laboratory environment.

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