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Keywords:

  • desorption electrospray ionization;
  • ion–surface reactions;
  • mass spectrometry;
  • peptide derivatization;
  • surface chemistry
Thumbnail image of graphical abstract

Chemical synthesis with ambient ions: Peptide cross-linking is achieved nearly instantaneously and quantitatively by delivering solvated peptide cations in microdroplets to a cross-linker present on a glass surface (see picture) or vice versa. The reaction can be carried out in an open laboratory environment.