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Peptide Cross-Linking at Ambient Surfaces by Reactions of Nanosprayed Molecular Cations


  • This research was supported by the National Science Foundation CHENSF 0848650.


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Chemical synthesis with ambient ions: Peptide cross-linking is achieved nearly instantaneously and quantitatively by delivering solvated peptide cations in microdroplets to a cross-linker present on a glass surface (see picture) or vice versa. The reaction can be carried out in an open laboratory environment.