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Keywords:

  • cucurbiturils;
  • cyclodextrins;
  • kinetic covalent chemistry;
  • positive cooperativity;
  • self-sorting
Thumbnail image of graphical abstract

In one fell swoop, polyrotaxanes comprising up to 64 rings can be synthesized as a result of cucurbit[6]uril-templated 1,3-dipolar azide-alkyne cycloadditions accelerated in the presence of cyclodextrins as a consequence of self-sorting and positive cooperativity, brought about by hydrogen bonding. Mixing six components (see picture) in one pot affords a hetero[4]rotaxane in one minute in quantitative yield.