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Keywords:

  • carbohydrates;
  • DNA;
  • glycoconjugates;
  • signal amplification;
  • ultrasensitive detection
Thumbnail image of graphical abstract

Tiny amounts of carbohydrates (ca. 1 zmol) can be detected quantitatively by a real-time method based on the conjugation of carbohydrates with DNA markers (see picture). The proposed method (glyco-qPCR) provides uniform, ultrasensitive detection of carbohydrates, which can be applied to glycobiology, as well as carbohydrate-based drug discovery.