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Keywords:

  • asymmetric synthesis;
  • diene;
  • macrolide;
  • silver catalysis;
  • umpolung
Thumbnail image of graphical abstract

Hidden symmetry within the THF-containing moieties of the macrocycle of amphidinolide F led S. Mahapatra and R. G. Carter to employ a synthetic strategy including a common intermediate, as reported in their Communication on page 7948 ff. The cover picture highlights key steps of the total synthesis as well as the locations on both sides of the Pacific of the initial characterization (Hokkaido University) and first synthesis (Oregon State University) of the natural product.