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Cover Picture
Inside Cover: Polyspermine Imidazole-4,5-imine, a Chemically Dynamic and Biologically Responsive Carrier System for Intracellular Delivery of siRNA (Angew. Chem. Int. Ed. 32/2012)
Article first published online: 23 JUL 2012
DOI: 10.1002/anie.201205175
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Duan, S., Yuan, W., Wu, F. and Jin, T. (2012), Inside Cover: Polyspermine Imidazole-4,5-imine, a Chemically Dynamic and Biologically Responsive Carrier System for Intracellular Delivery of siRNA (Angew. Chem. Int. Ed. 32/2012). Angew. Chem. Int. Ed., 51: 7864. doi: 10.1002/anie.201205175
Publication History
- Issue published online: 1 AUG 2012
- Article first published online: 23 JUL 2012
Keywords:
- biodegradable polymers;
- cytotoxicity;
- drug delivery;
- siRNA;
- spermine
Unlocking the endosome allows the release of siRNAs into the cytoplasm following the cellular uptake of nanoparticles made up of siRNAs and polyspermine imidazole-4,5-imine. In their Communication on page 7938 ff., T. Jin and co-workers show that a polymer of spermine with a pH-sensitive linkage degrades, upon entry into the endosome, into spermine and a nontoxic metabolite. Assays in cells and mice showed effective gene silencing by the polymer-packaged siRNAs without cytotoxicity.