Inside Cover: Polyspermine Imidazole-4,5-imine, a Chemically Dynamic and Biologically Responsive Carrier System for Intracellular Delivery of siRNA (Angew. Chem. Int. Ed. 32/2012)

Authors

  • Shiyue Duan,

    1. Laboratory of Drug Delivery and Biomaterials, School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Rd, Shanghai, 200240 (P.R. China)
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  • Weien Yuan,

    1. Laboratory of Drug Delivery and Biomaterials, School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Rd, Shanghai, 200240 (P.R. China)
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  • Fei Wu,

    1. Laboratory of Drug Delivery and Biomaterials, School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Rd, Shanghai, 200240 (P.R. China)
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  • Tuo Jin

    Corresponding author
    1. Laboratory of Drug Delivery and Biomaterials, School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Rd, Shanghai, 200240 (P.R. China)
    • Laboratory of Drug Delivery and Biomaterials, School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Rd, Shanghai, 200240 (P.R. China)
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Abstract

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Unlocking the endosome allows the release of siRNAs into the cytoplasm following the cellular uptake of nanoparticles made up of siRNAs and polyspermine imidazole-4,5-imine. In their Communication on page 7938 ff., T. Jin and co-workers show that a polymer of spermine with a pH-sensitive linkage degrades, upon entry into the endosome, into spermine and a nontoxic metabolite. Assays in cells and mice showed effective gene silencing by the polymer-packaged siRNAs without cytotoxicity.

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