SEARCH

SEARCH BY CITATION

Keywords:

  • asymmetric catalysis;
  • asymmetric synthesis;
  • heterocycles;
  • palladium;
  • stereoselectivity
Thumbnail image of graphical abstract

Positive water effect: A catalyst composed of [Pd2(dba)3] (dba=dibenzylideneacetone) and (S)-Siphos-PE is effective for the enantioselective coupling of N-allyl ureas with aryl bromides to afford 4-substituted imidazolidin-2-ones. Added water leads to significantly improved enantioselectivities with electron-poor aryl halide substrates. It is suggested that the C[BOND]C bond-forming reductive elimination is the enantiodetermining step in these reactions.