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Aptamer-Functionalized, Ultra-Small, Monodisperse Silica Nanoconjugates for Targeted Dual-Modal Imaging of Lymph Nodes with Metastatic Tumors


  • J.C. acknowledges support from the NIH (Director’s New Innovator Award 1DP2OD007246-01 and 1R21CA152627). L.T. was funded at University of Illinois at Urbana-Champaign from NIH National Cancer Institute Alliance for Nanotechnology in Cancer “Midwest Cancer Nanotechnology Training Center” Grant R25 CA154015A.


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A dual-modal imaging probe based on size-controlled silica nanoconjugates was synthesized for targeted imaging of lymph nodes by means of both PET and near infrared fluorescence techniques. 20 nm nanoconjugates (see scheme) functionalized with an aptamer (green triangles) that targets 4T1 breast cancer cells improved the detection efficiency of sentinel lymph nodes with metastatic tumors.