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Keywords:

  • coenzymes;
  • methylmalonyl-CoA mutase;
  • hydrogen bonds;
  • molecular dynamics;
  • negative catalysis
Thumbnail image of graphical abstract

Radical chaperone: Recent research reveals how the 5′-deoxyadenosyl radical (see structure) is generated by homolysis of the Co[BOND]C σ-bond of enzyme-bound coenzyme B12 and how it is guided to the substrate through pseudorotation of the ribose moiety and hydrogen-bonding interactions.