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Hydrogen Bonds Guide the Short-Lived 5′-Deoxyadenosyl Radical to the Place of Action

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  • This work was supported by the Max-Planck-Gesellschaft and the Deutsche Forschungsgemeinschaft (Schwerpunktprogramm 1319).

Abstract

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Radical chaperone: Recent research reveals how the 5′-deoxyadenosyl radical (see structure) is generated by homolysis of the Co[BOND]C σ-bond of enzyme-bound coenzyme B12 and how it is guided to the substrate through pseudorotation of the ribose moiety and hydrogen-bonding interactions.

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