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Strophasterols A to D with an Unprecedented Steroid Skeleton: From the Mushroom Stropharia rugosoannulata

Authors

  • Jing Wu,

    1. Graduate School of Science and Technology, Shizuoka University, 836 Ohya, Suruga-ku, Shizuoka 422-8529 (Japan)
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  • Dr. Shinji Tokuyama,

    1. Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University, 836 Ohya, Suruga-ku, Shizuoka 422-8529 (Japan)
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  • Dr. Kaoru Nagai,

    1. Department of Epigenetics Medicine, Interdisciplinary, Graduate School of Medicine and Engneering, University of Yamanashi, Yamanashi 409-3898 (Japan)
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  • Dr. Nobuhiro Yasuda,

    1. Japan Synchrotron Radiation Research Institute, Hyogo 679-5198 (Japan)
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  • Dr. Keiichi Noguchi,

    1. Instrumentation Analysis Center, Tokyo University of Agriculture and Technology Koganei, Tokyo 184-8588 (Japan)
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  • Tetsuo Matsumoto,

    1. Gunma Prefectural Forestry Experiment Station 2935 Arai, Gunma 370-3503 (Japan)
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  • Dr. Hirofumi Hirai,

    1. Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University, 836 Ohya, Suruga-ku, Shizuoka 422-8529 (Japan)
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  • Prof. Dr. Hirokazu Kawagishi

    Corresponding author
    1. Graduate School of Science and Technology, Shizuoka University, 836 Ohya, Suruga-ku, Shizuoka 422-8529 (Japan)
    2. Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University, 836 Ohya, Suruga-ku, Shizuoka 422-8529 (Japan)
    • Graduate School of Science and Technology, Shizuoka University, 836 Ohya, Suruga-ku, Shizuoka 422-8529 (Japan)
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  • This work was partially supported by the Japan Society for the Promotion of Science, and by a Grant-in-Aid for Scientific Research on lnnovative Areas “Chemical Biology of Natural Products” from The Ministry of Education, Culture, Sports, Science and Technology (Japan). We also thank T. Nishikawa (Nagoya University) and V. K. Deo (Shizuoka University) for valuable discussions. J.W. is a Research Fellow of the Japan Society for the Promotion of Science (Japan).

Abstract

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Skeletons in the closet: Four new compounds have been isolated from the title mushroom. The compounds display a new steroid skeleton (e.g., 1) not previously reported for steroids. Preliminary bioactivity tests show that compound 1 can protect neuronal cells by attenuating the endoplasmic reticulum stress, and has weak anti-methicillin-resistant Staphylococcus aureus activity.

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