Reciprocal Cross Talk between Fatty Acid and Antibiotic Biosynthesis in a Nematode Symbiont

Authors


  • The authors thank Tanja Schipper for help with the labeling experiments and Sebastian Fuchs for HRMS measurements. H.B.B. is grateful to the Deutsche Forschungsgemeinschaft (DFG) for financial support and work in his lab is additionally supported by the Bundesministerium für Bildung und Forschung (BMBF), the Frankfurt Initiative for Microbial Sciences (FIMS), and the European Community’s Seventh Framework Programme (FP7/2007-2013) under grant agreement no. 223328. J.P. is grateful to the DFG (SFB 624 and FOR 854).

Abstract

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Don't play the second fiddle! The identification of different arrangements of branched-chain keto acid dehydrogenases usually involved in the biosynthesis of cellular building blocks is demonstrated (see scheme). Direct cross talk between secondary metabolism ketosynthases (KS) and fatty acid biosynthesis is shown and the biosynthesis of odd-numbered iso-fatty acids is found to be connected to the production of pristinamycin IIa.

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