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Enzymatic Amine Acyl Exchange in Peptides on Gold Surfaces


  • This project was funded by the EPSRC, European Union FP6&7, Swiss National Science Foundation (to M.A.), and Royal Society (Wolfson Merit award to S.L.F.).


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Reversible as well as stereo- and chemoselective: Various proteases such as thermolysin and chymotrypsin catalyze amine acyl exchange in peptides. This acyl exchange can be used to modify amino-functionalized surfaces under physiological reaction conditions and provides an alternative mechanism for posttranslational transpeptidation reactions such as peptide-splicing reactions in the proteasome.

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