Acknowledgements are made to the Progetto FIRB “Futuro in Ricerca” Innovative sustainable synthetic methodologies for C-H activation processes, (MIUR, Rome) and the Università di Bologna. For support of the work in St. Andrews, the ERC (Advanced Researcher Award FUNCAT to S.P.N.) and the EPSRC are gratefully acknowledged. We also thank Prof. M. Monari for the X-ray analysis of 4 a. S.P.N. is a Royal Society Wolfson Research Merit Award holder.
One-Pot Gold-Catalyzed Synthesis of Azepino[1,2-a]indoles†
Article first published online: 3 SEP 2012
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 51, Issue 39, pages 9891–9895, September 24, 2012
How to Cite
Cera, G., Piscitelli, S., Chiarucci, M., Fabrizi, G., Goggiamani, A., Ramón, R. S., Nolan, S. P. and Bandini, M. (2012), One-Pot Gold-Catalyzed Synthesis of Azepino[1,2-a]indoles . Angew. Chem. Int. Ed., 51: 9891–9895. doi: 10.1002/anie.201205463
- Issue published online: 19 SEP 2012
- Article first published online: 3 SEP 2012
- Manuscript Received: 11 JUL 2012
- Università di Bologna
- cascade reactions;
- homogeneous catalysis;
- synthetic methods
Indoles from scratch: A gold(I)/N-heterocyclic carbene complex (IPr=1,3-di(isopropylphenyl)imidazol-2-ylidene) was found to be particularly effective as a catalyst, enabling the one-pot synthesis of tricyclic azepinoindoles by an unprecedented cascade reaction. Readily available substrates, high chemoselectivity, good yields, and water as the only stoichiometric by-product are some of the main advantages of this method.