We thank the Fonds der Chemischen Industrie and the European Research Council (ERC) for financial support. We also thank Evonik Industries AG (Hanau), and BASF AG (Ludwigshafen) for generous donations of chemicals.
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Communication
The ortho and meta Magnesiation of Functionalized Anilines and Amino-Substituted Pyridines and Pyrazines at Room Temperature†
Article first published online: 20 SEP 2012
DOI: 10.1002/anie.201205465
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Issue
Angewandte Chemie International Edition
Volume 51, Issue 42, pages 10624–10627, October 15, 2012
Additional Information
How to Cite
Monzón, G., Tirotta, I. and Knochel, P. (2012), The ortho and meta Magnesiation of Functionalized Anilines and Amino-Substituted Pyridines and Pyrazines at Room Temperature . Angew. Chem. Int. Ed., 51: 10624–10627. doi: 10.1002/anie.201205465
- †
Publication History
- Issue published online: 10 OCT 2012
- Article first published online: 20 SEP 2012
- Manuscript Received: 11 JUL 2012
Funded by
- Fonds der Chemischen Industrie
- European Research Council (ERC)
- Evonik Industries AG
- BASF
Corrected by:
Vol. 51, Issue 47, 11662, Article first published online: 14 NOV 2012
Keywords:
- aminoheterocycles;
- anilines;
- magnesiation;
- metalation
A practical ortho,meta, (or even ortho,ortho′) magnesiation of trifluoroacetamides of anilines, aminopyridines, and aminopyrazines at room temperature was performed with TMPMgCl⋅LiCl or TMP2Mg⋅2 LiCl. These magnesiations are compatible with several carbonyl functionalities and allow access to polysubstituted anilides in satisfactory yields.