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Keywords:

  • diffusion coefficients;
  • membrane proteins;
  • NMR spectroscopy;
  • phospholipids;
  • structure elucidation
Thumbnail image of graphical abstract

Microcoil NMR measurements were performed to determine the final composition of solutions of the β2-adrenergic receptor (β2AR) reconstituted with a detergent and to study the hydrodynamic properties of the detergent micelles containing β2AR (see picture). Standards are established for the reproducible preparation of G-protein-coupled receptor solutions for crystallization trials and solution NMR studies.