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Using Host–Guest Complexation to Fold a Flexible Linear Organic String: Kinetically Controlled Syntheses of [3]Catenanes and a Five-Membered Molecular Necklace

Authors

  • Chia-Fong Chang,

    1. Department of Chemistry, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei, Taiwan, 10617 (R.O.C.)
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  • Chun-Ju Chuang,

    1. Department of Chemistry, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei, Taiwan, 10617 (R.O.C.)
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  • Prof. Chien-Chen Lai,

    1. Institute of Molecular Biology, National Chung Hsing University and Graduate Institute of Chinese Medical Science, China Medical University, Taichung, Taiwan (R.O.C.)
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  • Yi-Hung Liu,

    1. Department of Chemistry, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei, Taiwan, 10617 (R.O.C.)
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  • Prof. Shie-Ming Peng,

    1. Department of Chemistry, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei, Taiwan, 10617 (R.O.C.)
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  • Prof. Sheng-Hsien Chiu

    Corresponding author
    1. Department of Chemistry, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei, Taiwan, 10617 (R.O.C.)
    • Department of Chemistry, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei, Taiwan, 10617 (R.O.C.)
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  • We thank the National Science Council (Taiwan) (NSC-100-2119-M-002-026 and NSC-101-2628-M-002-010) and National Taiwan University (NTU-101-R890913) for financial support.

Abstract

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Rings and necklaces: Three [3]catenanes and a five-membered molecular necklace ([5]MN), with up to 60- and 92-membered rings as their centerpieces, respectively, have been synthesized. The synthesis started from the corresponding complexes in which the threaded flexible linear guests were bent at approximately right angles to facilitate kinetically controlled macrocyclizations.

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