These authors contributed equally to this work.
Genomics-Driven Discovery of Burkholderic Acid, a Noncanonical, Cryptic Polyketide from Human Pathogenic Burkholderia Species†
Article first published online: 10 OCT 2012
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 51, Issue 46, pages 11611–11615, November 12, 2012
How to Cite
Franke, J., Ishida, K. and Hertweck, C. (2012), Genomics-Driven Discovery of Burkholderic Acid, a Noncanonical, Cryptic Polyketide from Human Pathogenic Burkholderia Species . Angew. Chem. Int. Ed., 51: 11611–11615. doi: 10.1002/anie.201205566
We thank A. Perner and H. Heineke for MS and NMR spectroscopy measurements, Dr. H. M. Dahse for preliminary biological assays and Dr. S. Pidot for critically reading the mansucript. This work was supported by the “Pakt für Forschung und Innovation” of the Free State of Thuringia and the BMBF, and the International Leibniz Research School for Biomolecular and Microbial Interactions (ILRS), as part of the excellence graduate school Jena School for Microbial Communication (JSMC).
- Issue published online: 7 NOV 2012
- Article first published online: 10 OCT 2012
- Manuscript Revised: 17 SEP 2012
- Manuscript Received: 13 JUL 2012
- Free State of Thuringia
- International Leibniz Research School for Biomolecular and Microbial Interactions (ILRS)
- quorum sensing
Biosynthetic secrets unveiled: Targeted promoter exchange in a cryptic biosynthesis gene cluster conserved among certain pathogenic Burkholderia species yielded a highly unstable, structurally unprecedented polyketide, burkholderic acid (1). Labeling experiments, gene knock-outs, and bioinformatics analyses grant first insights into a fascinating polyketide pathway. BurA is an unusual nonribosomal peptide synthetase/polyketide synthase featuring internal thioesterase domains.