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Keywords:

  • biosynthesis;
  • Burkholderia;
  • enyzmes;
  • polyketides;
  • quorum sensing
Thumbnail image of graphical abstract

Biosynthetic secrets unveiled: Targeted promoter exchange in a cryptic biosynthesis gene cluster conserved among certain pathogenic Burkholderia species yielded a highly unstable, structurally unprecedented polyketide, burkholderic acid (1). Labeling experiments, gene knock-outs, and bioinformatics analyses grant first insights into a fascinating polyketide pathway. BurA is an unusual nonribosomal peptide synthetase/polyketide synthase featuring internal thioesterase domains.