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Review
How Thiostrepton Was Made in the Laboratory
Article first published online: 3 DEC 2012
DOI: 10.1002/anie.201205576
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Issue
Angewandte Chemie International Edition
Volume 51, Issue 50, pages 12414–12436, December 7, 2012
Additional Information
How to Cite
Nicolaou, K. C. (2012), How Thiostrepton Was Made in the Laboratory. Angew. Chem. Int. Ed., 51: 12414–12436. doi: 10.1002/anie.201205576
Publication History
- Issue published online: 4 DEC 2012
- Article first published online: 3 DEC 2012
- Manuscript Received: 13 JUL 2012
Funded by
- National Institutes of Health
- The Skaggs Institute for Chemical Biology
- A*STAR Singapore
- Abstract
- Article
- References
- Cited By
Keywords:
- antibiotics;
- natural products;
- thiopeptides;
- thiostrepton;
- total synthesis
Abstract
Thiostrepton, a powerful antibiotic belonging to the thiopeptide class, was synthesized in the laboratory for the first time in 2004 through an arduous campaign involving novel strategies and tactics, scenic detours, and unexpected roadblocks. In this Review the author narrates the long journey to success, not so dissimilar to Odysseus’ return voyage to Ithaca, full of adventure, knowledge, and wisdom.†