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The Synthesis of η-1,2,3,4,5,6-Hexafluorocyclohexane (Benzene Hexafluoride) from Benzene


  • D.O’H. thanks the EPSRC and the ERC for an Advanced Investigator Grant to support this research. We thank the EPSRC for a research grant and for financial support through a DTG Studentship (A.J.D.).


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Six of the best: Benzene had been used by Faraday and Mitscherlich in their respective synthesis of hexachloro- and hexabromocyclohexane in the early 19th century. Also starting from benzene, η-1,2,3,4,5,6-hexafluorocyclohexane (benzene hexafluoride; see X-ray structure of a dimer) was now synthesized in five steps.

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