This work was supported by the National Science Foundation (CHE 1111550) and the National Institute of General Medical Sciences, and NIH (R01GM072667).
Chemical Synthesis of a Heparan Sulfate Glycopeptide: Syndecan-1†
Article first published online: 7 SEP 2012
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 51, Issue 40, pages 10185–10189, October 1, 2012
How to Cite
Yang, B., Yoshida, K., Yin, Z., Dai, H., Kavunja, H., El-Dakdouki, M. H., Sungsuwan, S., Dulaney, S. B. and Huang, X. (2012), Chemical Synthesis of a Heparan Sulfate Glycopeptide: Syndecan-1 . Angew. Chem. Int. Ed., 51: 10185–10189. doi: 10.1002/anie.201205601
- Issue published online: 26 SEP 2012
- Article first published online: 7 SEP 2012
- Manuscript Received: 14 JUL 2012
- National Science Foundation. Grant Number: CHE 1111550
- National Institute of General Medical Sciences
- synthesis design;
- total synthesis
Finishing first: The highly complex structure of the title compound (see picture) was assembled. The protective groups utilized, as well as the sequences for formation of the glycosyl linkages and protecting group removal are critical to the success of the synthesis. This first preparation of a heparan sulfate glycopeptide lays the foundation for accessing other members of this class of molecules.