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Chemical Synthesis of a Heparan Sulfate Glycopeptide: Syndecan-1


  • This work was supported by the National Science Foundation (CHE 1111550) and the National Institute of General Medical Sciences, and NIH (R01GM072667).


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Finishing first: The highly complex structure of the title compound (see picture) was assembled. The protective groups utilized, as well as the sequences for formation of the glycosyl linkages and protecting group removal are critical to the success of the synthesis. This first preparation of a heparan sulfate glycopeptide lays the foundation for accessing other members of this class of molecules.