A Nonmetal Approach to α-Heterofunctionalized Carbonyl Derivatives by Formal Reductive X[BOND]H Insertion


  • We thank the Pennsylvania State University for financial support of this research.


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Keeping it organic: A direct synthesis of α-alkoxy and α-amino ester derivatives by direct reductive coupling of widely available, stable α-keto esters and protic pronucleophiles is described (see scheme; X=OR, NR2). The method serves as a convenient nonmetal alternative to X[BOND]H insertion by diazo decomposition.