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Communication

A Supramolecular System for the Electrochemically Controlled Release of Cells†

  1. Dr. Qi An1,3,
  2. Jenny Brinkmann1,
  3. Prof.Dr. Jurriaan Huskens1,
  4. Sven Krabbenborg1,
  5. Prof. Dr. Jan de Boer2,
  6. Dr. Pascal Jonkheijm1,*

Article first published online: 4 NOV 2012

DOI: 10.1002/anie.201205651

Issue

Angewandte Chemie International Edition

Angewandte Chemie International Edition

Volume 51, Issue 49, pages 12233–12237, December 3, 2012

Additional Information

How to Cite

An, Q., Brinkmann, J., Huskens, J., Krabbenborg, S., de Boer, J. and Jonkheijm, P. (2012), A Supramolecular System for the Electrochemically Controlled Release of Cells . Angew. Chem. Int. Ed., 51: 12233–12237. doi: 10.1002/anie.201205651

Author Information

  1. 1

    Molecular Nanofabrication Group, Faculty of Science and Technology and MESA+Institute for Nanotechnology, University of Twente, P.O. Box 217, 7500 AE, Enschede (The Netherlands)

  2. 2

    MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, P.O. Box 217, 7500 AE, Enschede (The Netherlands)

  3. 3

    Current address: National Laboratory of Mineral Materials, School of Materials Science and Technology, China University of Geosciences, No.29, Xueyuan Road, 100083, Beijing, P. R. China

*Molecular Nanofabrication Group, Faculty of Science and Technology and MESA+Institute for Nanotechnology, University of Twente, P.O. Box 217, 7500 AE, Enschede (The Netherlands)

  1. †

    This research forms part of the Project P4.02 Superdices of the research program of the BioMedical Materials institute, co-funded by the Dutch Ministry of Economic Affairs, Agriculture and Innovation, and St-ERC Sumoman (259183). Artwork was obtained from www.nymus3d.nl.

Publication History

  1. Issue published online: 28 NOV 2012
  2. Article first published online: 4 NOV 2012
  3. Manuscript Received: 16 JUL 2012

Funded by

  • Dutch Ministry of Economic Affairs, Agriculture and Innovation
  • St-ERC Sumoman. Grant Number: 259183

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Keywords:

  • cell detachment;
  • host–guest systems;
  • stimuli responsive;
  • supramolecular chemistry
Thumbnail image of graphical abstract

Please release me: Electrochemically activated cell release is achieved using a redox-active supramolecular complex (see picture). Host molecule CB[8] (green) links surface-bound viologen (purple) with solution-exposed RGD peptides (red). Electrochemical reduction dissociates the complex, releases the peptides, and thus releases the cells from the substrates. This supramolecular strategy is also applicable to microelectrodes.

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