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A Supramolecular System for the Electrochemically Controlled Release of Cells

Authors

  • Dr. Qi An,

    1. Molecular Nanofabrication Group, Faculty of Science and Technology and MESA+Institute for Nanotechnology, University of Twente, P.O. Box 217, 7500 AE, Enschede (The Netherlands)
    2. Current address: National Laboratory of Mineral Materials, School of Materials Science and Technology, China University of Geosciences, No.29, Xueyuan Road, 100083, Beijing, P. R. China
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  • Jenny Brinkmann,

    1. Molecular Nanofabrication Group, Faculty of Science and Technology and MESA+Institute for Nanotechnology, University of Twente, P.O. Box 217, 7500 AE, Enschede (The Netherlands)
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  • Prof.Dr. Jurriaan Huskens,

    1. Molecular Nanofabrication Group, Faculty of Science and Technology and MESA+Institute for Nanotechnology, University of Twente, P.O. Box 217, 7500 AE, Enschede (The Netherlands)
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  • Sven Krabbenborg,

    1. Molecular Nanofabrication Group, Faculty of Science and Technology and MESA+Institute for Nanotechnology, University of Twente, P.O. Box 217, 7500 AE, Enschede (The Netherlands)
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  • Prof. Dr. Jan de Boer,

    1. MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, P.O. Box 217, 7500 AE, Enschede (The Netherlands)
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  • Dr. Pascal Jonkheijm

    Corresponding author
    1. Molecular Nanofabrication Group, Faculty of Science and Technology and MESA+Institute for Nanotechnology, University of Twente, P.O. Box 217, 7500 AE, Enschede (The Netherlands)
    • Molecular Nanofabrication Group, Faculty of Science and Technology and MESA+Institute for Nanotechnology, University of Twente, P.O. Box 217, 7500 AE, Enschede (The Netherlands)
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  • This research forms part of the Project P4.02 Superdices of the research program of the BioMedical Materials institute, co-funded by the Dutch Ministry of Economic Affairs, Agriculture and Innovation, and St-ERC Sumoman (259183). Artwork was obtained from www.nymus3d.nl.

Abstract

original image

Please release me: Electrochemically activated cell release is achieved using a redox-active supramolecular complex (see picture). Host molecule CB[8] (green) links surface-bound viologen (purple) with solution-exposed RGD peptides (red). Electrochemical reduction dissociates the complex, releases the peptides, and thus releases the cells from the substrates. This supramolecular strategy is also applicable to microelectrodes.

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