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Cover Picture
Cover Picture: Molecular Composition of Sub-stoichiometrically Labeled α-Synuclein Oligomers Determined by Single-Molecule Photobleaching (Angew. Chem. Int. Ed. 35/2012)
Article first published online: 13 AUG 2012
DOI: 10.1002/anie.201205691
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Zijlstra, N., Blum, C., Segers-Nolten, I. M. J., Claessens, M. M. A. E. and Subramaniam, V. (2012), Cover Picture: Molecular Composition of Sub-stoichiometrically Labeled α-Synuclein Oligomers Determined by Single-Molecule Photobleaching (Angew. Chem. Int. Ed. 35/2012). Angew. Chem. Int. Ed., 51: 8667. doi: 10.1002/anie.201205691
Publication History
- Issue published online: 22 AUG 2012
- Article first published online: 13 AUG 2012
Keywords:
- α-synuclein;
- photobleaching;
- proteins;
- single-molecule studies
In amyloid diseases, monomeric proteins self-assemble into supramolecular aggregates. In their Communication on page 8821 ff. V. Subramaniam et al. describe a new method that combines single-molecule photobleaching approaches with sub-stoichiometric labeling with fluorophores to determine the molecular composition of these large protein aggregates. The cover picture shows the aggregation of combinations of labeled and unlabeled monomers and the subsequent photobleaching analysis of single aggregates.