We thank the National Science Council, Taiwan, for financial support of this work.
Development of a Povarov Reaction/Carbene Generation Sequence for Alkenyldiazocarbonyl Compounds†
Article first published online: 18 OCT 2012
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 51, Issue 47, pages 11809–11813, November 19, 2012
How to Cite
Jadhav, A. M., Pagar, V. V. and Liu, R.-S. (2012), Development of a Povarov Reaction/Carbene Generation Sequence for Alkenyldiazocarbonyl Compounds . Angew. Chem. Int. Ed., 51: 11809–11813. doi: 10.1002/anie.201205692
- Issue published online: 14 NOV 2012
- Article first published online: 18 OCT 2012
- Manuscript Revised: 5 SEP 2012
- Manuscript Received: 17 JUL 2012
- National Science Council, Taiwan
- diazo compounds;
- synthetic methods
Rings aplenty: A HOTf-catalyzed (Tf=trifluoromethanesulfonyl) Povarov reaction of alkenyldiazo species has been developed and delivers diazo-containing cycloadducts stereoselectively (see scheme). The resulting cycloadducts provide access to six- and seven-membered azacycles through the generation of metal carbenes as well as the functionalization of diazo group.