Communication

Development of a Povarov Reaction/Carbene Generation Sequence for Alkenyldiazocarbonyl Compounds†

  1. Appaso Mahadev Jadhav,
  2. Vinayak Vishnu Pagar,
  3. Prof. Dr. Rai-Shung Liu*

Article first published online: 18 OCT 2012

DOI: 10.1002/anie.201205692

Issue

Angewandte Chemie International Edition

Angewandte Chemie International Edition

Volume 51, Issue 47, pages 11809–11813, November 19, 2012

Additional Information

How to Cite

Jadhav, A. M., Pagar, V. V. and Liu, R.-S. (2012), Development of a Povarov Reaction/Carbene Generation Sequence for Alkenyldiazocarbonyl Compounds . Angew. Chem. Int. Ed., 51: 11809–11813. doi: 10.1002/anie.201205692

Author Information

  1. Department of Chemistry, National Tsing Hua University, Hsinchu (30013) (Taiwan)

*Department of Chemistry, National Tsing Hua University, Hsinchu (30013) (Taiwan)

  1. †

    We thank the National Science Council, Taiwan, for financial support of this work.

Publication History

  1. Issue published online: 14 NOV 2012
  2. Article first published online: 18 OCT 2012
  3. Manuscript Revised: 5 SEP 2012
  4. Manuscript Received: 17 JUL 2012

Funded by

  • National Science Council, Taiwan

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Keywords:

  • carbenes;
  • cycloaddition;
  • diazo compounds;
  • heterocycles;
  • synthetic methods
Thumbnail image of graphical abstract

Rings aplenty: A HOTf-catalyzed (Tf=trifluoromethanesulfonyl) Povarov reaction of alkenyldiazo species has been developed and delivers diazo-containing cycloadducts stereoselectively (see scheme). The resulting cycloadducts provide access to six- and seven-membered azacycles through the generation of metal carbenes as well as the functionalization of diazo group.

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