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Fluorescent pH-Sensitive Nanoparticles in an Agarose Matrix for Imaging of Bacterial Growth and Metabolism


  • This work was financially supported by the Alexander von Humboldt foundation (Bonn) through a fellowship for X.-d.W. and the Deutsche Forschungsgemeinschaft (DFG) (project WO 669/9-1), which are gratefully acknowledged. We also want to express our special thanks to Barbara Goricnik for cultivating the bacteria.


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Living color: Fluorescent pH-sensitive nanoparticles 12 nm in diameter were prepared and incorporated into agarose gel in a Petri dish to image pH changes during bacterial growth and metabolism (see picture).