Support was provided by the NIH GM27681.
Pyrrole-Imidazole Polyamides Distinguish Between Double-Helical DNA and RNA†
Article first published online: 14 SEP 2012
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 52, Issue 1, pages 415–418, January 2, 2013
How to Cite
Chenoweth, D. M., Meier, J. L. and Dervan, P. B. (2013), Pyrrole-Imidazole Polyamides Distinguish Between Double-Helical DNA and RNA . Angew. Chem. Int. Ed., 52: 415–418. doi: 10.1002/anie.201205775
- Issue published online: 20 DEC 2012
- Article first published online: 14 SEP 2012
- Manuscript Received: 19 JUL 2012
- NIH. Grant Number: GM27681
- DNA recognition;
- RNA recognition
Groove specificity: Pyrrole-imidazole polyamides are well-known for their specific interactions with the minor groove of DNA (see scheme). However, polyamides do not show similar binding to duplex RNA, and a structural rationale for the molecular-level discrimination of nucleic acid duplexes by minor-groove-binding ligands is presented.