Get access

Pyrrole-Imidazole Polyamides Distinguish Between Double-Helical DNA and RNA

Authors

  • David M. Chenoweth,

    1. Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125 (USA)
    Search for more papers by this author
  • Jordan L. Meier,

    1. Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125 (USA)
    Search for more papers by this author
  • Prof. Peter B. Dervan

    Corresponding author
    1. Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125 (USA)
    • Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125 (USA)

    Search for more papers by this author

  • Support was provided by the NIH GM27681.

Abstract

original image

Groove specificity: Pyrrole-imidazole polyamides are well-known for their specific interactions with the minor groove of DNA (see scheme). However, polyamides do not show similar binding to duplex RNA, and a structural rationale for the molecular-level discrimination of nucleic acid duplexes by minor-groove-binding ligands is presented.

Ancillary