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Iron-Facilitated Oxidative Dehydrogenative C[BOND]O Bond Formation by Propargylic Cmath image[BOND]H Functionalization

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  • Financial support from the National Basic Research Program of China (973 Program 2009CB825300), the National Science Foundation of China (No. 21172006), and Peking University are greatly appreciated. We thank Zejun Xu in this group for reproducing the results of 3 ac, 3 ib, and 6 e.

Abstract

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Hot couple: Propargyl azides were coupled with carboxylic acids by an iron-catalyzed dehydrogenative C[BOND]O bond formation (see scheme). This method enables propargylic Cmath image[BOND]H functionalization under mild reaction conditions and also may involve the application of the azido moiety as an assisting group in C[BOND]H activation.

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