This work was supported by a grant from the Christian Doppler Research Society (CDG). D.C. thanks the Ministerio de Ciencia e Innovación of Spain for a scholarship. We also thank W. Gössler, W. Haas, and S. Mitsche for ICP-MS, TEM, and XRD analyses, respectively, and B. Gutmann for assistance with the continuous-flow experimentation.
In Situ Generated Iron Oxide Nanocrystals as Efficient and Selective Catalysts for the Reduction of Nitroarenes using a Continuous Flow Method†
Article first published online: 5 SEP 2012
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 51, Issue 40, pages 10190–10193, October 1, 2012
How to Cite
Cantillo, D., Baghbanzadeh, M. and Kappe, C. O. (2012), In Situ Generated Iron Oxide Nanocrystals as Efficient and Selective Catalysts for the Reduction of Nitroarenes using a Continuous Flow Method . Angew. Chem. Int. Ed., 51: 10190–10193. doi: 10.1002/anie.201205792
- Issue published online: 26 SEP 2012
- Article first published online: 5 SEP 2012
- Manuscript Received: 23 JUL 2012
- Christian Doppler Research Society (CDG)
- Ministerio de Ciencia e Innovación of Spain
- continuous flow;
- magnetic nanocrystals;
The best of both worlds: The benefits of homogeneous and heterogeneous nanocatalysis are combined, whereby highly reactive colloidal Fe3O4 nanocrystals are generated in situ that remain in solution long enough to allow the efficient and selective reduction of nitroarenes to anilines in continuous-flow mode (see scheme). After completion of the reaction, the nanoparticles aggregate and can be recovered by a magnet.