In Situ Generated Iron Oxide Nanocrystals as Efficient and Selective Catalysts for the Reduction of Nitroarenes using a Continuous Flow Method


  • This work was supported by a grant from the Christian Doppler Research Society (CDG). D.C. thanks the Ministerio de Ciencia e Innovación of Spain for a scholarship. We also thank W. Gössler, W. Haas, and S. Mitsche for ICP-MS, TEM, and XRD analyses, respectively, and B. Gutmann for assistance with the continuous-flow experimentation.


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The best of both worlds: The benefits of homogeneous and heterogeneous nanocatalysis are combined, whereby highly reactive colloidal Fe3O4 nanocrystals are generated in situ that remain in solution long enough to allow the efficient and selective reduction of nitroarenes to anilines in continuous-flow mode (see scheme). After completion of the reaction, the nanoparticles aggregate and can be recovered by a magnet.