SEARCH

SEARCH BY CITATION

Keywords:

  • heterocycles;
  • homogeneous catalysis;
  • hydrazones;
  • hydrogen bonding;
  • ion pairs
Thumbnail image of graphical abstract

A general, metal-free, highly enantioselective Brønsted acid catalyzed [3+2] cycloaddition between hydrazones and alkenes has been developed that affords pyrazolidine derivatives (see scheme). The resulting optically active pyrazolidines can undergo many chemical transformations which allow, for example, the enantioselective synthesis of valuable pyrazolines and 1,3-diamines.