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Subgel Phase Structure in Monolayers of Glycosylphosphatidylinositol Glycolipids


  • We are grateful to Prof. Dr. Helmuth Möhwald for helpful discussions and Sebastian Götze for providing a building block for synthesis of 1. We thank HASYLAB at DESY, Hamburg (Germany), for beamtime and excellent support. This work was supported by the Max Planck Society. The research leading to these results has received funding from the European Commission’s Seventh Framework Programme FP7/2007-2013 (postdoctoral fellowship to I.V.)


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Heads and tails: GPI glycolipid monolayers on the air/liquid interface are characterized by the ordering of entire molecules, as observed by grazing-incidence X-ray diffraction. Strong hydrogen bonding interactions are responsible for ordering of the head groups to form supercells. These forces are likely to be the key to the interactions of GPI-anchored proteins and/or GPIs in cell membranes.

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