Syntheses of Xanthofulvin and Vinaxanthone, Natural Products Enabling Spinal Cord Regeneration


  • We thank Dr. Wrigley for helpful discussions regarding 411J. Financial support from The University of Texas at Austin, the Welch Foundation (F-1694), and the NSF (CHE-1151708) are gratefully acknowledged.


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Growth promoting: The first synthesis of the natural product xanthofulvin (SM-216289) has resolved issues regarding its structural assignment and that described for the natural product 411J. The structurally and biologically related natural product vinaxanthone was similarly prepared through a novel dimerization reaction. Treatment of C. elegans with synthetic xanthofulvin and vinaxanthone enhanced axonal branching.