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Robust Helix Formation in a New Family of Oligoureas Based on a Constrained Bicyclic Building Block


  • We thank the CNRS, MESR and ANR (ANR-08-BLAN-0066-01) for financial support, and the SCBIM and Université de Lorraine for NMR and XRD facilities.


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BAC for more: A constrained bicyclic building block with urea linkages is an efficient combination for the formation of a highly rigid helical system. This type of bicyclic amino carbamoyl (BAC) foldamer was studied both in solution (see scheme) and in the solid state. A robust H-bond (dotted line) network was found between the carbonyl oxygen atoms (red) and the amino groups (dark blue) within the helix.

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