Financial support by the Loker Hydrocarbon Research Institute is gratefully acknowledged.
Copper-Mediated Difluoromethylation of (Hetero)aryl Iodides and β-Styryl Halides with Tributyl(difluoromethyl)stannane†
Article first published online: 25 OCT 2012
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 51, Issue 48, pages 12090–12094, November 26, 2012
How to Cite
Prakash, G. K. S., Ganesh, S. K., Jones, J.-P., Kulkarni, A., Masood, K., Swabeck, J. K. and Olah, G. A. (2012), Copper-Mediated Difluoromethylation of (Hetero)aryl Iodides and β-Styryl Halides with Tributyl(difluoromethyl)stannane . Angew. Chem. Int. Ed., 51: 12090–12094. doi: 10.1002/anie.201205850
- Issue published online: 21 NOV 2012
- Article first published online: 25 OCT 2012
- Manuscript Revised: 24 SEP 2012
- Manuscript Received: 24 JUL 2012
- Loker Hydrocarbon Research Institute
- CC coupling;
- density functional calculations;
Owing to their unique properties, molecules containing the difluoromethyl group (CF2H) are of great interest. Tributyl(difluoromethyl)stannane has now been used for the selective and efficient direct ipso difluoromethylation of aryl iodides, heterocyclic iodides, and β-styryl halides (see scheme). The straightforward preparation of the difluoromethylating reagent makes this approach particularly valuable.