Get access

Copper-Mediated Difluoromethylation of (Hetero)aryl Iodides and β-Styryl Halides with Tributyl(difluoromethyl)stannane

Authors

  • Prof. Dr. G. K. Surya Prakash,

    Corresponding author
    1. Loker Hydrocarbon Research Institute and Department of Chemistry, University of Southern California, University Park, Los Angeles, CA 90089-1661 (USA)
    • Loker Hydrocarbon Research Institute and Department of Chemistry, University of Southern California, University Park, Los Angeles, CA 90089-1661 (USA)
    Search for more papers by this author
  • Dr. Somesh K. Ganesh,

    1. Loker Hydrocarbon Research Institute and Department of Chemistry, University of Southern California, University Park, Los Angeles, CA 90089-1661 (USA)
    Search for more papers by this author
  • John-Paul Jones,

    1. Loker Hydrocarbon Research Institute and Department of Chemistry, University of Southern California, University Park, Los Angeles, CA 90089-1661 (USA)
    Search for more papers by this author
  • Dr. Aditya Kulkarni,

    1. Loker Hydrocarbon Research Institute and Department of Chemistry, University of Southern California, University Park, Los Angeles, CA 90089-1661 (USA)
    Search for more papers by this author
  • Kamil Masood,

    1. Loker Hydrocarbon Research Institute and Department of Chemistry, University of Southern California, University Park, Los Angeles, CA 90089-1661 (USA)
    Search for more papers by this author
  • Joseph K. Swabeck,

    1. Loker Hydrocarbon Research Institute and Department of Chemistry, University of Southern California, University Park, Los Angeles, CA 90089-1661 (USA)
    Search for more papers by this author
  • Prof. Dr. George A. Olah

    1. Loker Hydrocarbon Research Institute and Department of Chemistry, University of Southern California, University Park, Los Angeles, CA 90089-1661 (USA)
    Search for more papers by this author

  • Financial support by the Loker Hydrocarbon Research Institute is gratefully acknowledged.

Abstract

original image

Owing to their unique properties, molecules containing the difluoromethyl group (CF2H) are of great interest. Tributyl(difluoromethyl)stannane has now been used for the selective and efficient direct ipso difluoromethylation of aryl iodides, heterocyclic iodides, and β-styryl halides (see scheme). The straightforward preparation of the difluoromethylating reagent makes this approach particularly valuable.

Ancillary