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pH-Responsive Size-Tunable Self-Assembled DNA Dendrimers

Authors

  • Tao Zhou,

    1. Key Laboratory of Organic Optoelectronics & Molecular Engineering of the Ministry of Education, Department of Chemistry, Tsinghua University, Beijing 100084 (China)
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    • These authors contributed equally.

  • Ping Chen,

    1. State Key Laboratory of Polymer Physics and Chemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190 (China)
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    • These authors contributed equally.

  • Lin Niu,

    1. Beijing National Laboratory for Molecular Sciences, Department of Polymer Science and Engineering and the Key Laboratory of Polymer Chemistry and Physics of the Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871 (China)
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  • Juan Jin,

    1. Key Laboratory of Organic Optoelectronics & Molecular Engineering of the Ministry of Education, Department of Chemistry, Tsinghua University, Beijing 100084 (China)
    2. National Center for Nanoscience and Technology, Beijing 100190 (China)
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  • Prof. Dr. Dehai Liang,

    1. Beijing National Laboratory for Molecular Sciences, Department of Polymer Science and Engineering and the Key Laboratory of Polymer Chemistry and Physics of the Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871 (China)
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  • Prof. Dr. Zhibo Li,

    1. State Key Laboratory of Polymer Physics and Chemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190 (China)
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  • Prof. Dr. Zhongqiang Yang,

    1. Key Laboratory of Organic Optoelectronics & Molecular Engineering of the Ministry of Education, Department of Chemistry, Tsinghua University, Beijing 100084 (China)
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  • Prof. Dr. Dongsheng Liu

    Corresponding author
    1. Key Laboratory of Organic Optoelectronics & Molecular Engineering of the Ministry of Education, Department of Chemistry, Tsinghua University, Beijing 100084 (China)
    • Key Laboratory of Organic Optoelectronics & Molecular Engineering of the Ministry of Education, Department of Chemistry, Tsinghua University, Beijing 100084 (China)
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  • We thank the National Natural Science Foundation of China (No. 20974030, 91027046, 21121004) and the National Basic Research Program of China (973 program, No. 2013CB932803) for financial support.

Abstract

original image

Putting the DNA in dendrimers: A strategy to swiftly prepare DNA dendrimers based solely on DNA self-assembly is presented. This technique produces highly pure DNA dendrimers with an excellent yield of high generation dendrimers. The incorporation of molecular motors (i-motifs) into the DNA dendrimers allows for a change in size (up to 30%) in response to changing pH values (see scheme).

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