We thank the EPSRC for financial support and for a Leadership Fellowship (to H.W.L.). We thank Darryl W. Low (University of Edinburgh) for assistance in the preparation of substrates, and Gary S. Nichol (University of Edinburgh) for assistance with X-ray crystallography. Solvias AG and AllyChem are gratefully acknowledged for kind donations of chiral ligands and B2(pin)2, respectively. We thank the EPSRC National Mass Spectrometry Service Centre for providing high-resolution mass spectra.
Enantioselective Copper(I)-Catalyzed Borylative Aldol Cyclizations of Enone Diones†
Article first published online: 28 SEP 2012
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 51, Issue 43, pages 10827–10831, October 22, 2012
How to Cite
Burns, A. R., Solana González, J. and Lam, H. W. (2012), Enantioselective Copper(I)-Catalyzed Borylative Aldol Cyclizations of Enone Diones . Angew. Chem. Int. Ed., 51: 10827–10831. doi: 10.1002/anie.201205899
- Issue published online: 17 OCT 2012
- Article first published online: 28 SEP 2012
- Manuscript Received: 24 JUL 2012
- asymmetric catalysis;
- domino reactions;
Piña colato? In the presence of a chiral CuI/bisphosphine complex and B2(pin)2, enone diones undergo diastereo- and enantioselective desymmetrization to deliver highly functionalized bicyclic products. The products can be used as substrates in additional transformations. pin=pinacolato, Cy=cyclohexyl.