Research support from the Skaggs Institute for Chemical Biology is gratefully acknowledged. N.T. also thanks Daiichi Sankyo Co., Ltd. for financial support.
Organocatalytic Amidation and Esterification of Aldehydes with Activating Reagents by a Cross-Coupling Strategy†
Article first published online: 7 NOV 2012
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 51, Issue 50, pages 12538–12541, December 7, 2012
How to Cite
Tan, B., Toda, N. and Barbas, C. F. (2012), Organocatalytic Amidation and Esterification of Aldehydes with Activating Reagents by a Cross-Coupling Strategy . Angew. Chem. Int. Ed., 51: 12538–12541. doi: 10.1002/anie.201205921
- Issue published online: 4 DEC 2012
- Article first published online: 7 NOV 2012
- Manuscript Revised: 21 SEP 2012
- Manuscript Received: 24 JUL 2012
- Skaggs Institute
- Daiichi Sankyo Co., Ltd.
Formation on demand: An organocatalytic cross-coupling reaction of aldehydes with N-hydroxyimides, hexafluoroisopropyl alcohol, and sulfonimides has been developed. The resulting active intermediates can be directly converted into amides or esters in one pot. This simple method makes use of readily available starting materials, and the newly discovered activating reagents should find broad application in the synthesis of amides and esters.